News & Publication   

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  [Nat Commun. 2017 Oct] Integrative analysis of genomic and epigenomic regulation of the transcriptome in liver cancer

   우현구 교수 연구팀은 간암의 통합 오믹스 분석을 통해 새로운 간암아형 및 표적치료 타겟을 발굴하여 Nature Communications 학술지에 발표The study led by professor Hyun Goo Woo's laboratory performed a integrative multi-omics analysis for liver cancers, and developed a novel molecular subtypes and therapeutic targets, which was published in Nature Communications. In collaboration with Yoon Jun Kim. MD.PhD, a gastroenterologist at Seoul National University Hospital, they provided new biological and clinical insights on the pathobiology of the heterogenous progression of liver cancers.▶  관련논문 바로가기 ☞☞☞☞

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  [PNAS. 2018 Feb] DJ-1 deficiency impairs synaptic vesicle endocytosis and reavailability at nerve terminals.

   박상면 교수 연구팀은 경희대 의대 김성현 교수 연구팀과 함께 가족형 파킨슨병의 원인 유전자의 DJ-1 이 시냅스에 미치는 영향을 분석하여 이를 PNAS 학술지에 발표The study led by professor Sang Myun Park’s laboratory and professor Sung Hyun Kim’s laboratory at Kyung Hee University provides a novel role of DJ-1, a PD-associated gene product in synaptic vesicle endocytosis and reavailability, which was published in PNAS. This study implicates that the gene products causing familial PD operate through common molecular pathways that trigger neuronal degeneration and endocytic dysfunction is associated with the pathogenesis of  PD.▶  관련논문 바로가기 ☞☞☞☞

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  [Cell Rep. 2018 Jan] Prion-like Propagation of α-Synuclein Is Regulated by the FcγRIIB-SHP-1/2 Signaling Pathway in Neurons.

  박상면 교수 연구팀은 파킨슨병의 병인 기전에 매우 중요한  알파-시누클레인 세포간 전이현상의 분자기전을 밝혀내어 Cell Reports 에 보고함. The study led by professor Sang Myun Park’s laboratory provides the evidence that FcγRIIB expressed in neuron is a receptor for α-synuclein fibrils and FcγRIIB-SHP-1/-2 signaling pathway is involved in cell-to-cell transmission of α-synuclein, which was published in Cell Reports. This study implicates that FcγRIIB-SHP-1/-2 signaling pathway may be a therapeutic target for the progression of  PD.▶  관련논문 바로가기 ☞☞☞☞

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  [Circ Heart Fail. 2017 Sep] Dipeptidyl Peptidase-4 Inhibitors and Risk of Heart Failure in Patients With Type 2 Diabetes Mellitus: A Population-Based Cohort Study.

   의료정보학과 박래웅, 윤덕용 교수 연구팀은 전국민 심사평가 자료를 분석하여 ​dipeptidyl-petidase IV inhibitors (DPP-4i) 사용시 heart failure의 위험성을 평가한 내용을 ​CIRCULATION-HEART FAILURE 학술지에 발표In a study published in the journal CIRCULATION-HEART FAILURE, Rae Woong Park and Dukyong Yoon evaluated the risk of heart failure in patients who received dipeptidyl-petidase IV inhibitors (DPP-4i) by analyzing the cliam data of all Koreans from 2009 to 2015.Our findings suggest that DPP-4i use did not increase the risk of HF compared with sulfonylurea. The clinical implication of our study is that it provides a real-world evidence from nation-wide data for the controversial relationship.▶  관련논문 바로가기 ☞☞☞☞

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  [JID 2017 Aug] Fibroblast-Derived Clusterin Negatively Regulates Pigmentation

  강희영 교수 연구팀은 자외선에 의해 진피 섬유아세포 유래 분비물질인 클러스터린의 발현이 증가하며, 이 클러스터린의 미백 효능을 JOURNAL OF INVESTIGATIVE DERMATOLOGY (JID) 학술지에 발표The study led by professor Hee Young Kang's laboratory founded that fibroblast-derived clusterin negatively regulates pigmentation via TGF-β / Smad signaling activation, which was published in Journal of Investigative Dermatology. These results suggest that UV irradiation induces clusterin in skin and the fibroblasts derived-clusterin inhibits melanogenesis via cross-talk between fibroblast and melanocytes. Clusterin is a possible therapeutic target for the development of skin-lightening agents intended to treat hyperpigmentation.▶ 관련논문  바로가기  ☞☞☞☞

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  [Nat Commun 2017 Sep] An injectable hydrogel enhances tissue repair after spinal cord injury by promoting extracellular matrix remodeling.

  김병곤 교수 연구팀은 주사형 하이드로젤을 이용하여 손상된 척수조직을 재생하는 치료기술을 Nature Communications 학술지에 발표The study led by professor Byung Gon Kim's laboratory developed a novel therapeutic technology utilizing injectable hydrogel to repair injured CNS tissue, which was published in Nature Communications. In collaboration with biomaterial scientists at KIST, they provided evidence that injectable hydrogel can completely obliterate cystic cavities following traumatic CNS injury. This technique will be integrated with stem cell transplants and peptide drugs as a platform for multimodal regenerative medicine in neurological disorders.▶ 관련논문  바로가기  ☞☞☞☞